Reigning PFA Player of the Year De Bruyne returned from the facial fractures he suffered in last seasons Champions League final defeat by Chelsea to play for Belgium at the European Championship, only to suffer an ankle ligament tear during the tournament.
Meanwhile, fellow playmaker Foden missed out on Englands Euro 2020 final defeat by Italy with a foot injury.
Both players were sidelined for last weekends 1-0 Community Shield defeat by Leicester, with Pep Guardiola stating that the duo would be out for a while, with De Bruyne likely to return ahead of Foden.
The likes of Ederson, Gabriel Jesus, John Stones, Raheem Sterling and Kyle Walker were also absent from Wembley, but are now back in training following their summer international exertions.
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It remains to be seen which of that quintet will be fit enough to play some part this weekend, with the likes of Zack Steffen, Nathan Ake and Benjamin Mendy all deputising against Leicester along with youngsters Samuel Edozie and Cole Palmer.
New £100million signing Jack Grealish will be pushing for his maiden City start on Sunday following a 25-minute cameo off the bench at Wembley, but Guardiola said before the Community Shield that the former Aston Villa captain was not ready to start at all.
However, he might have to feature from the off here with the likes of Sterling and Jesus not yet up to speed.
The below prediction might have to be altered somewhat after Guardiolas pre-match press conference on Friday afternoon – so watch this space!
Man City predicted lineup (4-3-3): Ederson; Cancelo, Stones, Dias, Mendy; Rodri, Gundogan, Bernardo; Grealish, Ferran, Mahrez
Sunday 4.30pm BST, Sky Sports
Venue: Tottenham Hotspur Stadium
Referee: Anthony Taylor
Injury list: De Bruyne (ankle), Foden (foot)
Manchester City are set to remain without Kevin De Bruyne and Phil Foden as they begin their latest Premier League title defence at Tottenham this weekend.
